Fig. 3: Key addiction-related pathways are ubiquitously enriched with TESLA hits in multiple brain tissues. | Nature Genetics

Fig. 3: Key addiction-related pathways are ubiquitously enriched with TESLA hits in multiple brain tissues.

From: Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Fig. 3

We displayed TESLA enrichment P values (two sided) across 13 GTEx brain tissues using radar plots. a,b, The enrichment of TESLA hits for cigarettes per day for the dopaminergic synapse pathways (a) and the behavioral response to nicotine pathways (b). Gridlines in the radar plots indicate different levels of statistical significance. Each spoke represents a brain tissue and the length of the spoke represents the −log10(P) of enrichment. Brain tissues with significant enrichment P values after multiple testing corrections are shown in red. CC, cellular component; BP, biological process.

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