Table 1 TESLA identified substantially more loci and new loci than FE-TWASs, RE-TWASs and EURO-TWASs using GTEx data and PrediXcan weights

From: Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Genes identified across all the tissues

Trait

TESLA

FE-TWAS

RE-TWAS

EURO-TWAS

SmkInit

3,066 (908, 193)

2,916 (852, 168)

218 (84, 12)

2,729 (795, 132)

SmkCes

476 (155, 19)

414 (136, 16)

33 (19, 4)

428 (144, 16)

CigDay

840 (276, 46)

793 (248, 29)

482 (143, 31)

793 (229, 26)

AgeInit

93 (50, 15)

64 (38, 8)

8 (7, 3)

29 (21, 2)

Total

4475 (1,389, 273)

4187 (1,274, 221)

741 (147, 50)

3979 (1,189, 176)

  1. Genes with two-sided TWAS P values <2.5 × 10−6 were deemed statistically significant. A gene × trait association was considered new if it was >1 × 106 bp away from previously reported GWAS hits. The number of gene × trait associations, the number of unique gene × trait associations (that is, the gene × trait association that appears in multiple tissues are counted only once) and new associations are shown for each TWAS method. The numbers in parentheses are unique gene and new gene counts, respectively
Back to article page