Extended Data Fig. 2: GIE in primary and metastatic tumors.
From: Genetic immune escape landscape in primary and metastatic cancer
a) Workflow of the sample processing pipeline used in this study in Hartwig (left) and PCAWG (right). Each rectangle represents a processing step. The resulting number of selected samples for this study are displayed at the bottom. Sample-exclusion criteria for LILAC is described in Supp. Note 1. b) number of metastatic (Hartwig) samples across cancer types that lack sufficient representation in the primary (PCAWG) dataset. c) Analogous representation for primary (PCAWG) samples. Vertical dashed lines (N>= 15 samples) represent the threshold of samples to consider a cohort as sufficiently populated.
