Extended Data Fig. 5: RCMC identifies microcompartments, which are not visible in other methods and not reliably called by existing algorithms. | Nature Genetics

Extended Data Fig. 5: RCMC identifies microcompartments, which are not visible in other methods and not reliably called by existing algorithms.

From: Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments

Extended Data Fig. 5

(a, b) Contact maps comparison of RCMC (top) against Hi-C31 (bottom, a) and Micro-C12 (bottom, b) at the Klf1 locus at 500 and 250 bp resolutions and at the Ppm1g locus at 1000 and 250 bp resolutions. (c) Contact maps of the Klf1 and Ppm1g loci at 1 kb resolution with loop calls by Mustache37 overlaid on the bottom half of the map and compartment calls by cooltools59,60 shown below the map. (d) Contact maps of the entire Klf1 (3.2 kb resolution) and Ppm1g (5 kb resolution) captured loci with manually called loops (see Methods) overlaid on the bottom halves of the maps.

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