Extended Data Fig. 4: RCMC maps the Sox2 locus more deeply and efficiently than sister methods, uncovering previously unseen interactions.
From: Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments
(a) Contact map comparisons of RCMC against Hi-C31 (top) and Micro-C12 (bottom) at the Sox2 locus at 1.6 kb resolution. Arrows mark contacts between Sox2, the SCR, and Fxr1 not mapped by Hi-C and Micro-C. (b) Contact map comparisons of RCMC against Tiled-Micro-Capture-C17 (TMCC) across the whole TMCC-Captured locus (left, 1600 bp resolution) and in the Sox2 and SCR regulatory cluster (right, 500 bp resolution). Full datasets are visualized in the top contact maps, and TMCC has been downsampled to match the total number of RCMC sequencing reads in view in the bottom contact maps.
