Extended Data Fig. 6: Enrichment tests for the GWAS candidate gene set against human ortholog gene sets that when genetically manipulated in mice result in “Abnormal Antibody Levels” or “Abnormal Immunoglobulin A Levels”. | Nature Genetics

Extended Data Fig. 6: Enrichment tests for the GWAS candidate gene set against human ortholog gene sets that when genetically manipulated in mice result in “Abnormal Antibody Levels” or “Abnormal Immunoglobulin A Levels”.

From: Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Extended Data Fig. 6

a, Plot for “Abnormal Antibody Levels”. b, Plot for “Abnormal Immunoglobulin A Levels”. The x-axis depicts gene rank by statistical significance. The y-axis depicts −log10 of two-sided P-value based on the enrichment test without multiple testing correction. The red horizontal line is the Bonferroni-corrected statistical significance level corrected for the number of genes tested.

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