Extended Data Fig. 2: Regional plots for non-HLA genome-wide significant loci. | Nature Genetics

Extended Data Fig. 2: Regional plots for non-HLA genome-wide significant loci.

From: Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Extended Data Fig. 2

a, The FCRL locus. b, The TNFSF4 locus. c, The CFH locus. d, The REL locus. e, The CD28 locus. f, The PF4V1/CXCL8 locus. g, The IRF4 locus. h, The RREB1 locus. i, The DEFA locus. j, The LYN locus. k, The ANXA3 locus. l, The TNFSF8 locus. m, The CARD9 locus. n, The REEP3 locus. o, The ZMIZ1 locus. p, The RELA locus. q, The ETS1 locus. r, The IGH locus. s, The ITGAM locus. t, The IRF8 locus. u, The TNFSF13 locus. v, The TNFRSF13B locus. w, The FCAR locus. x, The HORMAD2/LIF locus. The x-axis shows the physical position in Mb (hg19 coordinates) and known genes. The left y-axis presents −log10 of two-sided P-values for variant association statistics (fixed effects meta-analysis under an additive model without correction for multiple testing), and the right y-axis shows the recombination rate across the region. The dotted horizontal line indicates a genome-wide significance threshold of 5.0 × 10−8.

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