Extended Data Fig. 5: Frequent inactivation of lymphoid or B-cell development genes.
From: Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia
a, Oncoprint of alterations in lymphoid or B-cell development genes in decreasing order of recurrence rate. b, Histogram of the number of lymphoid or B-cell development genes altered in diagnostic leukemias. Mean number is 2.1. c, Frequency of homozygous losses of IKZF1 by subtype. p-value from Fisher’s exact test is shown. d, Frequency of dominant negative Ik6 deletion by subtype. p-value from Fisher’s exact test is shown. e, Gene expression score for stromal cell signature15 by subtype (26 Early-Pro, 8 Inter-Pro, 23 Late-Pro leukemias). f. Normalized counts (RNA-seq) of IL7R transcripts by subtype (26 Early-Pro, 8 Inter-Pro, 23 Late-Pro leukemias). g, Mutation loads (SNV and indel counts) by subtype. p-values from pairwise Wilcoxon rank-sum tests and Kruskal-Wallis test are shown. Data from primary leukemias with a median genome coverage of 15.8x are shown (12 Early-Pro, 3 Inter-Pro, 13 Late-Pro).
