Extended Data Fig. 4: Global changes in SSIM due to global alterations of genome organization.
From: Reply to: Revisiting the use of structural similarity index in Hi-C
a, SSIM profiles for comparisons of Hi-C experiments from Wutz et al. 2017 (ref. 7). In each case unmodified (‘WT’) HeLa cells were used as the reference for the comparison and the query sample is shown in the legend. All cells are synchronised in G1 phase unless otherwise stated. b, Normalised Hi-C data at 50 kb resolution for an example region on chr2, for the datasets from A. c, Overall SSIM distributions for the comparisons in A. Point and lines show mean ± one standard deviation across 301–305 4 Mb windows with valid SSIM values. d, Overall SN distributions for the comparisons in A. Point and lines show mean ± one standard deviation across 301–305 4 Mb windows with valid SSIM values. e, Pearson’s correlations of the SSIM profile for comparisons in A with genomic coverage of the Hi-C datasets used in the comparison.
