New research reports that paused RNA polymerase II (RNAPII) enhances the targeting and activity of BAF chromatin remodelers. These findings suggest a new paradigm for understanding how the collaborative action of chromatin remodelers and the transcriptional machinery govern cell-type-specific chromatin accessibility.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer
Cell Death & Disease Open Access 28 August 2025
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ho, L. & Crabtree, G. R. Nature 463, 474–484 (2010).
Brahma, S. & Henikoff, S. Nat. Genet. https://doi.org/10.1038/s41588-023-01603-8 (2023).
Core, L. & Adelman, K. Genes Dev 33, 960–982 (2019).
Kaya-Okur, H. S. et al. Nat. Commun. 10, 1930 (2019).
Janssens, D. et al. Genome Biol 23, 81 (2022).
Papillon, J. P. N. et al. J. Med. Chem. 61, 10155–10172 (2018).
Macrae, T. et al. Nat. Rev. Mol. Cell Biol. 24, 9–26 (2023).
King, H. W. et al. Genome Res 28, 1494–1507 (2018).
Kadoch, C. et al. Nat. Genet. 49, 213–222 (2016).
Kim, J. M. et al. eLife 10, e69387 (2021).
Tilly, B. C. et al. eLife 10, e69424 (2021).
Martin, B. et al. Cell 186, 5290–5307 (2023).
Henninger, J. E. et al. Cell 184, 207–225 (2023).
Patil, A. et al. Cell 186, 4936–4955 (2023).
Boehning, M. et al. Nat. Struct. Mol. Biol. 25, 833–840 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Chick, B.Y., Hargreaves, D.C. RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling. Nat Genet 56, 19–20 (2024). https://doi.org/10.1038/s41588-023-01628-z
Published:
Issue date:
DOI: https://doi.org/10.1038/s41588-023-01628-z
This article is cited by
-
ACTL6A depletion induces KLF4-mediated anti-tumorigenic effects in colorectal cancer
Cell Death & Disease (2025)
