Extended Data Fig. 5: MAGMA cell-type enrichment analysis in midbrain. | Nature Genetics

Extended Data Fig. 5: MAGMA cell-type enrichment analysis in midbrain.

From: Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Extended Data Fig. 5

MAGMA gene-property analysis of 25 midbrain cell types (GSE76381) indicates enrichment of GABAergic neurons, GABAergic neuroblasts and mediolateral neuroblasts. Vertical bars depict −log10 P values from one-sided t-tests for enrichment. Significant cell types are colored blue and gray if not. The dotted horizontal line indicates statistical significance adjusted for the number of comparisons (P < 0.05/25). The asterisk (*) indicates that GABAergic neurons remained significant in stepwise conditional analysis of the other significant cell types. Abbreviations: Gaba, GABAergic neurons; NbGaba, neuroblast gabaergic; NbML1-5, mediolateral neuroblasts; DA0-2, dopaminergic neurons; Sert, serotonergic neurons; RN, red nucleus; Rgl 1-3, radial glia-like cells; NbM, medial neuroblasts; OPC, oligodendrocyte precursor cells; ProgFPL, progenitor lateral floorplate; OMTN, oculomotor and trochlear nucleus; Endo, endothelial cells; ProgM, progenitor midline; NProg, neuronal progenitor; ProgBP, progenitor basal plate; Mgl, microglia; ProgFPM, progenitor medial floorplate; Peric, pericytes.

Back to article page