Fig. 3: An RNA-binding surface in EZH2, but not its RNA-binding activity, is required for maintaining transcription programs in lineage-committed cells.

a, Unsupervised clustering of genome-wide correlation between H3K27me3 CUT&Tag data from Fig. 2. Values in boxes represent Pearson’s correlation coefficients between corresponding samples. Different samples are represented by color codes at the top and the left of the plot, with the color key is indicated at the bottom left of the figure. Three independent replicates were carried out on three different days, with different replicates indicated to the right and the bottom of the plot (rep). b, RNA-seq was carried out on cell lines that were prepared according to the same scheme as in Fig. 2a. PCA of the RNA-seq data is color coded as in panel a. RNA-seq recorded from four independent biological replicates that were carried out on four different days.