Extended Data Fig. 1: Variant calling, global selection and somatic mutations in UK Biobank. | Nature Genetics

Extended Data Fig. 1: Variant calling, global selection and somatic mutations in UK Biobank.

From: Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis

Extended Data Fig. 1

a. Age distribution from UKBB. b. Pipeline for identifying exome wide selection on somatic mutations and new genes under positive selection in UKBB. c. Global dN/dS estimates per age group. Error bars represent the 95% CI of the dN/dS parameter for that mutation type and age group. N = 52,701 mutations. d. Percent of mutation type per age group. e. Number of mutations for each mutation type per age group.

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