Extended Data Fig. 4: Proximity bias correction in DepMap Data. | Nature Genetics

Extended Data Fig. 4: Proximity bias correction in DepMap Data.

From: High-resolution genome-wide mapping of chromosome-arm-scale truncations induced by CRISPR–Cas9 editing

Extended Data Fig. 4

a, Split genome-wide heatmap built from 625 CRISPR cell lines, 190 shRNA cell lines, and 11,169 genes shared between CRISPR and shRNA datasets in the DepMap 19Q3 and DEMETER2 v6 data. CRISPR-Cas9 data are shown above the diagonal and shRNA data below. No proximity bias signal is visible in the shRNA data. b, Quantification of proximity bias in the DepMap shRNA dataset with colors showing Bonferroni-corrected p-values from the one-sided arm-level Brunner-Munzel test. Only a few chromosome arms display significant deviation of intra- versus inter-chromosome-arm similarities contrasting with the CRISPR data shown in Fig. 3b.

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