Extended Data Fig. 3: Manhattan plot of rare coding variant association meta-analysis. | Nature Genetics

Extended Data Fig. 3: Manhattan plot of rare coding variant association meta-analysis.

From: Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease

Extended Data Fig. 3

We tested 2,738,849 rare missense and protein truncating variants from 604,915 individuals in the UK Biobank, the All of Us Research Program and the BioMe Biobank. Dotted horizontal line represents an exome-wide significance threshold of P = 4.3 × 10−7. We obtained two-sided base 10 logarithm P-values from a fixed-effect inverse-variance weighted meta-analysis. Italicized text indicates gene names.

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