Extended Data Fig. 9: Contribution of PGS to inter-individual variation of prediction SDs in All of Us.
From: Calibrated prediction intervals for polygenic scores across diverse contexts
We compared inter-individual variation of prediction SDs in two models: (1) prediction mean as a function of all contexts without PGS; (2) include PGS as part of prediction mean in the baseline model. Prediction SD is modeled as a function of all contexts in both models. By comparing prediction SDs in these two models, we found including PGS substantially impacted inter-individual variation in prediction SD.
