Extended Data Fig. 9: Model for mtDNA heteroplasmy change.
From: Mitochondrial DNA mosaicism in normal human somatic cells
a–d, Contour plots representing how clone-VAF of PZsimple mtDNA mutations changes with continuous mitotic turnover from simulation studies assuming four different baseline mtDNA copy numbers, including 500 (a), 1,000 (b), 1,500 (c) and 2,000 (d) and absolute mutation rate of 5.0 × 10−8 per bp replication. The x axis shows the mitotic turnover count and the y axis shows the top heteroplasmy level of postzygotic mutation.
