Extended Data Fig. 6: Relationship between proliferation index and RNA subtypes. | Nature Genetics

Extended Data Fig. 6: Relationship between proliferation index and RNA subtypes.

From: Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Extended Data Fig. 6

The association with an RNA-seq-defined proliferation index and CoMMpass subtypes is shown (n = 714). The Bergsagel proliferation index27 for each sample was determined by calculating the geometric mean expression of 12 genes (TYMS, TK1, CCNB1, MKI67, KIAA101, KIAA0186, CKS1B, TOP2A, UBE2C, ZWINT, TRIP13 and KIF11). The PR subtype had the highest median proliferation index score. The index range is shown as a boxplot with the upper and lower bounds of the box representing the 25th and 75th percentile, while the center line indicates the median and whiskers represent the highest and lowest value within 1.5 (IQR).

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