African American patients were under-represented in the studies that led to the current patient classification system for acute myeloid leukemia (AML). A new in-depth analysis of the genetics of AML in African Americans suggests that this omission has implications for patient care.
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References
Madanat, Y. F., Kalaycio, M. E. & Nazha, A. Acta Med. Acad. 48, 35–44 (2019).
Döhner, H., Weisdorf, D. J. & Bloomfield, C. D. N. Engl. J. Med. 373, 1136–1152 (2015).
Ley, T. J. et al. N. Engl. J. Med. 368, 2059–2074 (2013).
Duncavage, E. J. et al. N. Engl. J. Med. 384, 924–935 (2021).
Khoury, J. D. et al. Leukemia 36, 1703–1719 (2022).
Dohner, H. et al. Blood 140, 1345–1377 (2022).
Spratt, D. E. et al. JAMA Oncol. 2, 1070–1074 (2016).
Abraham, I. E. et al. Blood 139, 2212–2226 (2022).
Abecasis, G. R. et al. Nature 491, 56–65 (2012).
Bryc, K., Durand, E. Y., Macpherson, J. M., Reich, D. & Mountain, J. L. Am. J. Hum. Genet. 96, 37–53 (2015).
Jiagge, E. et al. Ann. Surg. Oncol. 23, 3843–3849 (2016).
Carrot-Zhang, J. et al. Cancer Cell 37, 639–654.e6 (2020).
Jiagge, E. et al. Cancer Cell 41, 1963–1971.e3 (2023).
Stiff, E. et al. Nat. Genet. https://doi.org/10.1038/s41588-024-01929-x (2024).
Abecasis, G. et al. Nature 491, 56–65 (2012).
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Jiagge, E.M. Genetic African ancestry modifies the biology of acute myeloid leukemia. Nat Genet 56, 2299–2301 (2024). https://doi.org/10.1038/s41588-024-01869-6
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DOI: https://doi.org/10.1038/s41588-024-01869-6