Extended Data Fig. 6: Additional transcriptomic and chromatin accessibility characterization following DB2115 exposure. | Nature Genetics

Extended Data Fig. 6: Additional transcriptomic and chromatin accessibility characterization following DB2115 exposure.

From: Pharmacological restriction of genomic binding sites redirects PU.1 pioneer transcription factor activity

Extended Data Fig. 6

(a) Comparison of log2fold change in PU.1 peak score (DB2115-treated/Vehicle) with log2fold change of ATAC peak score (colored according to PU.1 CUT&Tag groups). (b) Comparison of log2fold change in PU.1 peak score (DB2115-treated/Vehicle) with log2fold change of RNA expression of associated genes (colored according to PU.1 peak groups). (c) A high confidence list of promoter/intronic/exonic DB2115-target genes being either lost/closing (194) or gained/opening (506) were analyzed for enrichment of pathways from GO biological processes using the molecular signature database. (d) K-means clustering of normalized and binarized raw count ATAC data from Corces et al., 2016; confirming correct groupings of cellular identity, used for Fig. 4p, q.

Back to article page