Extended Data Fig. 9: Comparison of silencer sets identified by the Higher-Order Interaction Test and a hypothetical additive model for K562, GM12878 and PC-3.
From: Interpreting cis-regulatory interactions from large-scale deep neural networks
a–c, Comparison of the average fold change over wild-type (WT) for silencer sets for sequences categorized as silencing context versus a hypothetical additive effects model for K562 (a), GM12878 (b), PC-3 (c). The sequences from silencing contexts are stratified according to interaction type, superadditivity and additivity. Shaded region represents standard deviation of the mean. Notably, we did not identify any subadditivity cases.
