Extended Data Fig. 4: The cumulative incidence of breast-, prostate- and colorectal cancer.
From: Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
The cumulative incidence curves, 1-S(t), where S(t) is the survival function estimated with the Kaplan-Meier method, are shown for non-carriers and carriers for all genes that associate significantly in the burden association scan with a-b. breast cancer, c-d. prostate cancer and e-f. colorectal cancer. In a, c, e the cumulative incidence is shown among chip-typed individuals in Iceland (N=173,025) and in b, d, f the cumulative incidence is shown among white British/Irish individuals in the UK Biobank (N=431,079).
