Using reported parental disease history to decipher the genetics of Alzheimer’s disease may be promising, but this approach is also susceptible to complex selection and information bias that can mislead researchers if not accounted for.
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References
Liu, J. Z., Erlich, Y. & Pickrell, J. K. Nat. Genet. 49, 325–331 (2017).
Hujoel, M. L. A., Gazal, S., Loh, P.-R., Patterson, N. & Price, A. L. Nat. Genet. 52, 541–547 (2020).
Pedersen, E. M. et al. Am. J. Hum. Genet. 109, 417–432 (2022).
Marioni, R. E. et al. Transl. Psychiatry 8, 99 (2018).
Bellenguez, C. et al. Nat. Genet. 54, 412–436 (2022).
Wu, Y. et al. Nat. Genet. https://doi.org/s41588-024-01963-9 (2024).
Lee, S. H., Wray, N. R., Goddard, M. E. & Visscher, P. M. Am. J. Hum. Genet. 88, 294–305 (2011).
Tyrrell, J. et al. Nat. Commun. 12, 886 (2021).
Fry, A. et al. Am. J. Epidemiol. 186, 1026–1034 (2017).
Pirastu, N. et al. Nat. Genet. 53, 663–671 (2021).
Schoeler, T. et al. Nat. Hum. Behav. 7, 1216–1227 (2023).
Mitchell, R. E. et al. PLoS Genet. 19, e1010596 (2023).
Demange, P. A. et al. Nat. Genet. 53, 35–44 (2021).
Pedersen, E. M. et al. Nat. Commun. 14, 5553 (2023).
van Alten, S., Domingue, B. W., Faul, J., Galama, T. & Marees, A. T. Int. J. Epidemiol. 53, (2024).
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B.J.V. is a member of the scientific advisory board for Allelica. E.M.P. and T.W. declare no competing interests.
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Pedersen, E.M., Wimberley, T. & Vilhjálmsson, B.J. A cautionary tale for Alzheimer’s disease GWAS by proxy. Nat Genet 56, 2590–2591 (2024). https://doi.org/10.1038/s41588-024-02023-y
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DOI: https://doi.org/10.1038/s41588-024-02023-y
