Extended Data Fig. 5: Cell-type annotation for the mesenchymal lineage using UMAP plots. | Nature Genetics

Extended Data Fig. 5: Cell-type annotation for the mesenchymal lineage using UMAP plots.

From: Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

Extended Data Fig. 5

a, Lineage-level UMAP for mesenchymal cells generated after final cell-type annotation. b, Proportion of the total number of mesenchymal cells by disease state (unaffected, less affected or more affected). Alveolar fibroblast cells are the majority mesenchymal cell type across all groups, although the proportion of disease-associated, activated fibrotic fibroblasts increases in PF. c,d, Select cell-type gene markers visualized in UMAP space across all mesenchymal cells (c) and split by cell type (d). For c and d, boxes indicate the cell type the gene marks. Gray-dashed lines indicate general mesenchymal lineage markers.

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