Extended Data Fig. 6: Localization of key cell types. | Nature Genetics

Extended Data Fig. 6: Localization of key cell types.

From: Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

Extended Data Fig. 6

a–c, Representative examples of (a) pathologic SCGB3A2+/SCGB1A1− airways near airways with mixed populations of SCGB3A2−/SCGB1A1+ and SCGB3A2+/SCGB1A1+ (RASC) dual-positive cells and SCGB3A+/SFTPC+ (transitional AT2) cells in remodeled alveoli; (b,c) WNT5A+ myofibroblasts surrounding conducting airways; (c) PI1+/MFAP5+ adventitial fibroblasts near vasculature. Transcript expression is overlain on H&E images. d, Density plots showing expression of disease-enriched endothelial marker COL15A1 and pan-endothelial marker PECAM1 in representative unaffected and PF samples. Samples depicted are as follows: (a) VUILD78MA (IPAF diagnosis), (b–d) TILD175MA (IPF) and (d) VUHD095 (unaffected). Scale bars represent 20 µm.

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