Extended Data Fig. 10: KRT5−/KRT17+ cell detachment in matched Xenium and Visium HD data. | Nature Genetics

Extended Data Fig. 10: KRT5−/KRT17+ cell detachment in matched Xenium and Visium HD data.

From: Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

Extended Data Fig. 10

a,b, Examples of KRT5−/KRT17+ cells detaching from the basement membrane are shown for two samples (a, VUILD49LA—cHP diagnosis; b, TILD113LA—IPF) that were processed with both Xenium and Visium HD. For each panel, an H&E stain is shown with brackets denoting areas of epithelial detachment. Scale bars represent 20 µm. For Xenium images (top), select transcripts are shown to mark KRT5−/KRT17+ cells (left) and activated fibrotic fibroblasts (right). Each transcript is a point or other shape, colored by gene as listed in the legend. For Visium HD images (bottom), the sum of the log2 expression of a list of genes (Supplementary Table 11) is shown as a density map overlain on the H&E.

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