Extended Data Fig. 1: MESA demonstrates robust neighborhood characterization results across distinct scRNA-seq datasets of tonsil tissues for multiomics integration.
From: Quantitative characterization of tissue states using multiomics and ecological spatial analysis
(A) mRNA-based neighborhood characterization results obtained from integrating the tonsil CODEX data with the scRNA-seq data from40, as in the analysis shown in Fig. 2. The top panel shows the tonsil tissue with MESA-identified neighborhoods displayed in distinct colors. The bottom panel provides a magnified view of a representative germinal center region. (B) Neighborhood characterization results from integrating the tonsil CODEX data with an independent scRNA-seq data from41. While there are some minor differences between the two analyses, the consistency in key spatial patterns and structures demonstrates MESA’s robustness across different scRNA-seq data sources.
