Extended Data Fig. 9: Additional analysis for snATAC–seq and Xenium. | Nature Genetics

Extended Data Fig. 9: Additional analysis for snATAC–seq and Xenium.

From: Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan

Extended Data Fig. 9

a,b, Peak accessibility for PT(S3) populations across ages and sexes. STAT5A, STAT5B and BCL6 within the promoter regions were highlighted. The peaks shown were the promoter regions of (a) Socs2 and (b) Prlr. c, Xenium single-cell spatial expressions of 5 sex-dimorphic spatial patterns in W12 mice. (Top) Zonal sex-biased spatial expression example annotated with range for Cortex (red lines) and outer stripe of the outer medulla (OSOM; yellow lines). (Bottom) Diagram for the zonal pattern expression. Dots indicate the expression of the gene in that zone. d, Single-cell spatial expressions of Jak2, Prlr and Socs2 of W12 female and male mice using Xenium platform. F, female; M, male; E16.5, embryonic 16.5; P0, newborn; W3, week 3; W12, week 12; W52, week 52; W92, week 92.

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