Fig. 4: Sex differences in PT revealed by regulatory network analysis.
a, Heatmap for the averaged binary activity of cell-type-specific regulons in PT segments across all samples from age E16.5 to W92. Top rows indicate cell type, sex and age. The ‘(number g)’ notation indicates the number of genes in the regulon. b, Heatmap of genes involved in Socs2 expression regulation. c,d, Expression of PT(S3)-derived, female-biased genes predicted to be downstream targets of both STAT5 and BCL6 (c) and controlled strictly by STAT5 (d). Reference bars on top indicate sex and age. e, Sex-biased regulatory mechanism diagram, controlled by STAT5 and BCL6 together (left), or controlled by STAT5 alone (right). Red boxes show female-biased genes and blue boxes show male-biased genes.
