Fig. 2: A synteny-based algorithm, IPP, identifies thousands of putative sequence orthologs of mouse heart CREs. | Nature Genetics

Fig. 2: A synteny-based algorithm, IPP, identifies thousands of putative sequence orthologs of mouse heart CREs.

From: Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Fig. 2

a, Schematic of the IPP algorithm and its classification of DC, IC and NC features. b, Increase in number of available anchor points in a representative region of the mouse genome using 0, 1 and 14 bridging species. c, IPP increased the number of putative orthologs from mouse in 15 other species used as bridging species (compare blue versus orange portion). LiftOver alignments (top bar) are compared with IPP DC and IC alignments. The increase was particularly high at greater evolutionary distances from nonmammalian species. d, PhastCons77way scores for IPP-defined classes promoters and enhancers. Boxplot shows median and interquartile range of scores of 500-bp windows centered by IPP projections in chicken. Promoter n = 4,461 DC, 9,237 IC, 6,532 NC; enhancer n = 2,588 DC, 10,162 IC, 16,712 NC. d, distance to anchor point.

Source data

Back to article page