Extended Data Fig. 3: Interspecies Point Projection increases detection of putative ortholog regions compared to alignment-based methods. | Nature Genetics

Extended Data Fig. 3: Interspecies Point Projection increases detection of putative ortholog regions compared to alignment-based methods.

From: Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Extended Data Fig. 3

(a) IPP projections compared to LiftOver determined orthologs using variable minMatch thresholds. (b) Overlap of DC and IC projections with LiftOver-determined orthologs (minMatch=0.1) (c) IPP performance compared to halliftover/HALPER for mouse heart enhancer ortholog prediction in four placental mammals. (d-f) IPP projections for forelimb CREs at E10.5 & E11.5 (d), randomly selected genomic regions and published heart enhancers (Blow et al 2010) (e), adult liver CREs (f). (g) IPP projections for mouse CEBP/A ChIP-seq peaks and number of conserved binding events (as determined by overlap with a CEBP/A ChIP-seq peaks in chicken livers).

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