How primary gallbladder tumors evolve to acquire immunosuppressive and pro-metastatic capabilities remains unclear. A study using single-cell RNA sequencing coupled with spatial profiling and functional experiments has pinpointed mechanisms of immune-mediated tumor cell reprogramming, fostering disease progression.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Martínez-Ruiz, C. et al. Nature 616, 543–552 (2023).
McDonald, O. G. et al. Nat. Genet. 49, 367–376 (2017).
Makohon-Moore, A. P. et al. Nat. Genet. 49, 358–366 (2017).
Zhou, T. et al. Nat. Genet. https://doi.org/10.1038/s41588-025-02236-9 (2025).
Nakamura, H. et al. Nat. Genet. 47, 1003–1010 (2015).
Mody, K. et al. JCO Precis. Oncol. 6, e2100510 (2022).
Nepal, C. et al. J. Hepatol. 74, 1132–1144 (2021).
Roa, J. C. et al. Nat. Rev. Dis. Primers 8, 69 (2022).
Chung, T. et al. J. Hepatol. https://doi.org/10.1016/j.jhep.2025.01.007 (2025).
Sans, M. et al. Cancer Discov. 13, 1844–1861 (2023).
Messal, H. A. et al. Nature 566, 126–130 (2019).
Guzelsoy, G. et al. Nature 640, 534–542 (2025).
Rohani, N. et al. Cancer Res. 79, 1952–1966 (2019).
Luo, M. et al. Cancer Discov. 15, 511–529 (2025).
Koshiol, J. et al. Gastroenterology 153, 488–494.e1 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
O’Rourke, C.J., Andersen, J.B. Spatial and temporal dynamics in progressive gallbladder cancer. Nat Genet 57, 1796–1797 (2025). https://doi.org/10.1038/s41588-025-02232-z
Published:
Issue date:
DOI: https://doi.org/10.1038/s41588-025-02232-z
