Extended Data Fig. 5: Phylogenetic trees and mutational signatures in individuals treated with alkylating agents.
From: The long-term effects of chemotherapy on normal blood cells
a, Phylogenetic tree of 48-year-old chemotherapy exposed female (PD47703). Branch lengths correspond to SBS burdens. A stacked bar plot represents the SBS mutational signatures contributing to each branch with colour code below the trees. SBSUnassigned indicates mutations that could not confidently be assigned to any reported signature. She had been treated with chlorambucil and procarbazine at age 10 (early), and bendamustine at age 47 (late). b, Phylogenetic trees and SBS mutational signatures in individuals treated with cyclophosphamide.
