Fig. 4: Mutation burden and SBS mutational signatures across different blood cell types.
From: The long-term effects of chemotherapy on normal blood cells
Stacked bar plots represent the absolute contributions of each SBS mutational signature to the SBS mutation burden across cell types (left), compared to the proportionate contribution of each signature (right). HSPC data were generated by pooling HSPC WGS colony data from each individual. Mature blood cell data were generated using duplex sequencing of ~40,000 cells of each type. For the normal unexposed individuals, the T cell subset data are from CD4+ T cells; for the chemotherapy-exposed individuals, the T cell subsets contain both CD4+ and CD8+ T cells. SBSUnassigned indicates mutations that could not confidently be assigned to any reported signature. SBSNA indicates that duplex sequencing data are unavailable for this subset. In seven individuals, granulocyte mutation profiles were available, which were not discernibly different from the mutational spectra observed in HSPCs and monocytes from those individuals. Due to the lack of availability of this cell type for most patients, the data are not shown.
