Extended Data Fig. 2: SBS-C signature profiles and driver mutation links in melphalan-treated HSPC clades. | Nature Genetics

Extended Data Fig. 2: SBS-C signature profiles and driver mutation links in melphalan-treated HSPC clades.

From: Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation

Extended Data Fig. 2

a, The pairwise association plot displays the cosine similarity metrics between pairs of mutation signatures, with the strength of associations represented by color intensity. The actual mutational signature plots for SBS-MM1 and SBS-C are also shown. b, Box plots comparing the proportion of SBS-C signatures among clades with or without driver mutations (n.d.) in PID0003 and PID0004. None of the comparisons showed statistical significance. Box plots show the median (line), upper and lower quartiles (box) ±1.5× interquartile range (whiskers). PID0003: PPM1D p.R458X (n = 7), TET2 p.S710fs (n = 10), TP53 p.G245D (n = 4), TP53 p.H179D (n = 28), n.d. (n = 43), PID0004: PPM1D p.C478X (n = 40), PPM1D p.R552X (n = 6), PPM1D p.S468X (n = 6), PPM1D p.W427X (n = 3), n.d. (n = 16). n.d., no driver mutations.

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