Extended Data Fig. 3: Association between germline predisposition genes and subtypes of hematologic malignancies in the UK Biobank.
From: Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Heatmap showing the log hazard ratio for hematologic malignancy subtypes among germline pathogenic variants carriers of genes that predispose to both CH and hematologic malignancies compared to non-carriers. ‘Secondary’ refers to hematologic cancers occurring after a solid tumor diagnosis. Hazard ratios were obtained from Cox regression adjusted for age at blood draw, the first three genetic principal components, and exome sequencing batch. *P < 0.05. Two-sided P value is not corrected for multiple hypothesis testing. AML, acute myeloid leukemia; MPN, myeloproliferative neoplasms; MDS, myelodysplastic syndromes; CML, chronic myelogenous leukemia; NHL, non-Hodgkin’s lymphoma; HL, Hodgkin’s lymphoma; CLL, chronic lymphocytic leukemia; MM, multiple myeloma.
