Fig. 1: Miami plot of EUR female and EUR male GWAS.
The EUR female association study (top panel) included 570,071 total samples (40,137 self-reported stuttering cases) and 29,449,463 autosomal variants. Nine loci reached genome-wide significance (dotted line, P < 5.00 × 10−8) through logistic regression (see Methods). The EUR male association study (bottom panel) included 374,279 total samples (38,257 self-reported stuttering cases) and 29,409,446 autosomal variants. Ten loci reached genome-wide significance (dotted line, P < 5.00 × 10−8) through logistic regression (see Methods). The x axis represents chromosome base pair coordinates in human genome build 37, and the y axis represents observed −log10(P) for each analysis. Annotated genes for each GWAS are the predicted functional gene for each locus (when available) according to the Open Targets Genetics V2G pipeline (see Methods).
