Extended Data Fig. 4: Manhattan and Q-Q plots for the sex-combined meta-analyses.
Manhattan plots for sex-combined meta-analyses performed using the inverse variance weighted option in METAL (see Methods). The dotted line represents genome-wide significance (P < 5 × 10−8). Q-Q plot x-axes represent expected −log10(P-value), and y-axes represent observed −log10(P-value) with 95% CI indicated by shaded region. a, The meta-analysis includes 944,350 total samples (78,394 self-reported stuttering cases) and 29,566,899 autosomal variants observed across EUR male and EUR female GWAS; λgc = 1.0586. b, The meta-analysis includes 119,393 total samples (13,555 self-reported stuttering cases) and 29,948,846 autosomal variants observed across AMR male and AMR female GWAS; λgc = 1.0070. c, The meta-analysis includes 20,516 total samples (2,339 self-reported stuttering cases) and 10,656,266 autosomal variants observed across EAS male and EAS female GWAS; λgc = 1.0023. d, The meta-analysis includes 38,760 total samples (5,488 self-reported stuttering cases) and 29,705,842 autosomal variants observed across AFR male and AFR female GWAS; λgc = 1.0019.
