Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

A Tribal data repository to advance Indigenous health and sovereignty

Nature Genetics (2025)Cite this article

Subjects

We present the first federally funded Tribal data repository — the Data for Indigenous Implementations, Interventions, and Innovations Tribal Data Repository. This repository takes a revolutionary approach to data management by building space for researchers to engage with data from Indigenous groups under rigorous Tribal Nation governance and by prioritizing community data-sharing interests.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Four core activities of D4I TDR.
Fig. 2: TDR data flow and architecture for D4I TDR.
Fig. 3: D4I TDR approval workflow.

References

  1. Narlock, M. R., Calvert, S., Taylor, S., Márquez, R. P. & Parkman, A. Data Sci. J. 23, 46 (2024).

    Article  Google Scholar 

  2. Hrynaszkiewicz, I., Simons, N., Hussain, A., Grant, R. & Goudie, S. Data Sci. J. 19, 5

  3. Wilkinson, M. D. et al. Sci. Data 3, 160018 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Doerr, M. & Meeder, S. Ethics Hum. Res. 44, 34–38 (2022).

    Article  PubMed  Google Scholar 

  5. Garrison, N. A. Daedalus 147, 60–69 (2018).

    Article  Google Scholar 

  6. Guillemin, M. et al. Int. J. Equity Health 15, 8 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Hudson, M. et al. Nat. Rev. Genet. 21, 377–384 (2020).

    Article  CAS  PubMed  Google Scholar 

  8. Halmai, N. B. et al. Annu. Rev. Genomics Hum. Genet. (2025).

  9. Carroll, S. R. et al. Data Sci. J. 19, 43 (2020).

    Article  Google Scholar 

  10. James, R. et al. Genet. Med. 16, 820–826 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Wallerstein, N. B. & Duran, B. Health Promot. Pract. 7, 312–323 (2006).

    Article  PubMed  Google Scholar 

  12. Claw, K. G. et al. Nat. Commun. 9, 2957 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Carroll, S. R., Herczog, E., Hudson, M., Russell, K. & Stall, S. Sci. Data 8, 108 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Gifford, H. & Mikaere, K. Te Rau Ora 4, 6–14 (2025).

    Google Scholar 

  15. Pickering, K. et al. Environ. Res. Lett. 18, 033001 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Genomic Science Innovation, University of Wisconsin – Madison, Madison, WI, USA

    Matthew Z. Anderson, Charee L. Peters, Sakiah Perez Rivera & Justin Billy

  2. Laboratory of Genetics, University of Wisconsin – Madison, Madison, WI, USA

    Matthew Z. Anderson

  3. Center for Biology and Society, School of Life Science, Arizona State University, Tempe, AZ, USA

    Krystal S. Tsosie, Claire Banta, Ruben Cu:k Ba’ak & Karina Hernandez-Hernandez

  4. Department of Bioethics and Humanities, University of Washington School of Medicine, Seattle, WA, USA

    Susan Brown Trinidad

  5. Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA

    Ann Mc Cartney

  6. School of Biology and Environmental Science, University College Dublin, Dublin, Ireland

    Ann Mc Cartney

  7. Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA

    Soledad Fernandez

  8. Center for Biostatistics, The Ohio State University, Columbus, OH, USA

    Soledad Fernandez & Neena A. Thomas

  9. Native BioData Consortium, Eagle Butte, SD, USA

    Kali J. Dale, Rebecca Dickinson, Guthrie Ducheneaux, Ashlynn Gerth & Joseph M. Yracheta

  10. Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH, USA

    Oindrila Bhattacharyya

  11. Sploosh.AI, Seattle, WA, USA

    Rob Brennan

  12. School of Complex Adaptive Systems, Arizona State University, Tempe, AZ, USA

    Kelle Dhein

  13. Department of Biomedical Education and Anatomy, Center for Bioethics, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Dana S. Howard

  14. College of Public Health, The Ohio State University, Columbus, OH, USA

    Efthimios Parasidis

  15. Moritz College of Law, The Ohio State University, Columbus, OH, USA

    Efthimios Parasidis

Authors
  1. Matthew Z. Anderson
    View author publications

    Search author on:PubMed Google Scholar

  2. Krystal S. Tsosie
    View author publications

    Search author on:PubMed Google Scholar

  3. Charee L. Peters
    View author publications

    Search author on:PubMed Google Scholar

  4. Susan Brown Trinidad
    View author publications

    Search author on:PubMed Google Scholar

  5. Ann Mc Cartney
    View author publications

    Search author on:PubMed Google Scholar

  6. Soledad Fernandez
    View author publications

    Search author on:PubMed Google Scholar

  7. Kali J. Dale
    View author publications

    Search author on:PubMed Google Scholar

  8. Sakiah Perez Rivera
    View author publications

    Search author on:PubMed Google Scholar

  9. Claire Banta
    View author publications

    Search author on:PubMed Google Scholar

  10. Oindrila Bhattacharyya
    View author publications

    Search author on:PubMed Google Scholar

  11. Justin Billy
    View author publications

    Search author on:PubMed Google Scholar

  12. Rob Brennan
    View author publications

    Search author on:PubMed Google Scholar

  13. Ruben Cu:k Ba’ak
    View author publications

    Search author on:PubMed Google Scholar

  14. Kelle Dhein
    View author publications

    Search author on:PubMed Google Scholar

  15. Rebecca Dickinson
    View author publications

    Search author on:PubMed Google Scholar

  16. Guthrie Ducheneaux
    View author publications

    Search author on:PubMed Google Scholar

  17. Ashlynn Gerth
    View author publications

    Search author on:PubMed Google Scholar

  18. Karina Hernandez-Hernandez
    View author publications

    Search author on:PubMed Google Scholar

  19. Dana S. Howard
    View author publications

    Search author on:PubMed Google Scholar

  20. Efthimios Parasidis
    View author publications

    Search author on:PubMed Google Scholar

  21. Neena A. Thomas
    View author publications

    Search author on:PubMed Google Scholar

  22. Joseph M. Yracheta
    View author publications

    Search author on:PubMed Google Scholar

Corresponding authors

Correspondence to Matthew Z. Anderson or Joseph M. Yracheta.

Ethics declarations

Competing interests

J.M.Y. is executive director of the Native BioData Consortium (NativeBio). M.Z.A., G.D. and K.S.T. are board members for NativeBio. All other authors declare no competing interests.

Peer review

Peer review information

Nature Genetics thanks Maui Hudson for their contribution to the peer review of this work.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Anderson, M.Z., Tsosie, K.S., Peters, C.L. et al. A Tribal data repository to advance Indigenous health and sovereignty. Nat Genet (2025). https://doi.org/10.1038/s41588-025-02382-0

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41588-025-02382-0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing