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Walking over the inflammasome

Nature Chemical Biology volume 15, pages 552–553 (2019)Cite this article

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The NLRP3 inflammasome contributes to pathogenic inflammation in a broad range of diseases, making it a highly relevant drug target. Two studies published in this issue found an inhibitor of NLRP3 inflammasome activation to directly bind NLRP3 within its central NACHT domain, interfering with ATP hydrolysis and structural changes critical for NLRP3 oligomerization and subsequent inflammasome formation.

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Fig. 1: MCC950 action on NLRP3.

References

  1. Martinon, F., Mayor, A. & Tschopp, J. Annu. Rev. Immunol. 27, 229–265 (2009).

    Article  CAS  Google Scholar 

  2. Coll, R. C. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0277-7 (2019).

  3. Tapia-Abellán, A. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0278-6 (2019).

    Article  PubMed  Google Scholar 

  4. Duncan, J. A. et al. Proc. Natl. Acad. Sci. USA 104, 8041–8046 (2007).

    Article  CAS  Google Scholar 

  5. Brydges, S. D. et al. Immunity 30, 875–887 (2009).

    Article  CAS  Google Scholar 

  6. Shao, B. Z., Xu, Z. Q., Han, B. Z., Su, D. F. & Liu, C. Front Pharmacol. 6, 262 (2015).

    Article  Google Scholar 

  7. Perregaux, D. G. et al. J. Pharmacol. Exp. Ther. 299, 187–197 (2001).

    CAS  PubMed  Google Scholar 

  8. Coll, R. C. et al. Nat. Med. 21, 248–255 (2015).

    Article  CAS  Google Scholar 

  9. van Hout, G. P. et al. Eur. Heart J. 38, 828–836 (2017).

    PubMed  Google Scholar 

  10. Jiang, H. et al. J. Exp. Med. 214, 3219–3238 (2017).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Oliver Gorka, Emilia Neuwirt & Olaf Groß

  2. Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

    Olaf Groß

Authors
  1. Oliver Gorka
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  2. Emilia Neuwirt
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  3. Olaf Groß
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Correspondence to Olaf Groß.

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The authors declare no competing interests.

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Gorka, O., Neuwirt, E. & Groß, O. Walking over the inflammasome. Nat Chem Biol 15, 552–553 (2019). https://doi.org/10.1038/s41589-019-0292-8

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