Extended Data Fig. 7: YY1 promotes interactions between DNA elements containing its consensus sequence motifs, G4 DNA, or both.
From: YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression
a, A scheme depicting the in vitro proximity ligation assay for assessing the ability of YY1 to enhance DNA-DNA interactions involving G4 structures and/or YY1 consensus motifs. b, qPCR quantification results of the proximity ligation products formed between motifs, between G4 structures, and between motif and G4 structure in the presence or absence of YY1 protein. c, qPCR quantification results revealed the inability of YY1 in promoting the ligation between M4 (that is mutated sequence of G4 that can no longer fold into G4 structure) and G4, motif, or M4. d, qPCR quantification results of the proximity ligation products formed between G4 structures in the absence or presence of PDS or TMPyP4. The data represent mean ± S.E.M. of results from three independent experiments.
