Fig. 2: YY1 interacts with G4 structure in cells.
From: YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression
a, Comparisons of YY1 ChIP–seq data with BG4 ChIP–seq data. b, A Venn diagram showing the overlap between YY1 ChIP–seq and BG4 ChIP–seq peaks. c, Comparison of YY1 ChIP–seq data acquired for cells with or without (Ctrl) PDS/TMPyP4 treatment. The P values were calculated by using the hypergeometric test. d,e, Enrichment ratios of YY1 ChIP–seq peaks containing different motifs after treatment with PDS (d) or TMPyP4 (e). BG4, peaks overlapped with BG4 ChIP–seq peaks; Y, peaks containing YY1 consensus motif; BG4Y, peaks containing both YY1 consensus motif and overlapped with BG4 ChIP–seq. The data in d and e represent mean ± s.e.m. In d, n = 370, 1,194 and 638 for BG4, Y and BG4Y, respectively; in e, n = 378, 1,198 and 639 for BG4, Y and BG4Y, respectively. In d and e the two-tailed Student’s t-test was used to calculate the P values. ***P < 0.001; P = 3.1 × 10−15 for Y and P = 1.6 × 10−20 for BG4Y in d; P = 2.0 × 10−6 for Y and P = 5.0 × 10−11 for BG4Y in e. f,g, Chromatin localization of YY1 after PDS (f) or TMPyP4 (g) treatment, where the experiments were performed independently three times with similar results.
