Fig. 5: Regulation of gene expression by YY1 promoter G4 interactions.
From: YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression
a–d, Dot plot showing the correlation of gene expression between PDS-treated and shYY1-1-treated (a), shYY1-2-treated (b), shYY1-1 + PDS-treated (c), or shYY1-2 + PDS-treated (d) cells. Shown are average ratios of RNA-seq results from two biological replicates; n = 14,707 genes for Pearson correlation calculation in a–d. e–g, Quantification results of mRNA expression levels of MANF (e), PDHB (f) and PGBD5 (g) genes in HEK293T cells with shRNA-mediated knockdown of YY1 and/or after PDS/TMPyP4 treatment. Top of each panel shows read enrichments from BG4 ChIP–seq and YY1 ChIP–seq. The data represent mean ± s.e.m. of results from three independent experiments.
