Fig. 6: YY1–G4 binding participates in transcription regulation of the TRMT12 gene through long-range DNA looping.
From: YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression
a, Read enrichments obtained from BG4 ChIP–seq and YY1 ChIP–seq results. b, Normalized interaction frequency involving the sites linked with a red arch in a in HEK293T cells with or without PDS or TMPyP4 treatment, as captured by YY1 HiChIP. c, Quantification of mRNA expression levels of TRMT12 in HEK293T cells after knockdown of YY1 and/or with PDS/TMPyP4 treatment. The data represent mean ± s.e.m. of results from three independent experiments.
