Extended Data Fig. 4: Computational design, experimental screening and enrichment analysis of the 4E2H design series.
From: Bottom-up de novo design of functional proteins with complex structural features
a, TopoBuilder assembly of the 4E2H topology and full-atom structure after Rosetta FunFolDes. b, Detailed view on all positions experimentally sampled (green). c, Enrichment analysis. n = 3,903 unique sequences were analyzed that were found under both selection conditions. d, Residue preferences for indicated position in positively enriched versus negatively enriched sequences. See Extended Data Fig. 2 caption for further details.
