Extended Data Fig. 5: Computational design, experimental screening and enrichment analysis of the 3H1L_02 design series.
From: Bottom-up de novo design of functional proteins with complex structural features
a, TopoBuilder assembly of the 3H1L_02 topology and full-atom structure after Rosetta FunFolDes, the epitope region is highlighted in purple. b, Detailed view on all positions experimentally sampled (green). c, Enrichment analysis. n = 99,338 unique sequences were analyzed that were found under both selection conditions. d, Residue preferences for indicated position in positively enriched versus negatively enriched sequences. See Extended Data Fig. 2 caption for further details.
