Extended Data Fig. 6: Computational design, experimental screening and enrichment analysis of the 4H design series.
From: Bottom-up de novo design of functional proteins with complex structural features
a, TopoBuilder assembly of the 4H topology and full-atom structure after Rosetta FunFoldDes, the Mota epitope region is colored in cyan and 2D10 epitope is colored in wheat. b, Detailed view on all positions experimentally sampled (green). c, Enrichment analysis. n = 287 unique sequences were analyzed that were found under both selection conditions. d, Residue preferences for indicated position in positively enriched versus negatively enriched sequences. See Extended Data Fig. 2 caption for further details.
