Extended Data Fig. 8: ASGClpXP -expressing cells showed higher contrast to tissue with nonlinear imaging.
From: Acoustic biosensors for ultrasound imaging of enzyme activity
B-mode and xAM contrast-to-tissue ratio (CTR) in vivo, for WT Nissle cells expressing ARGWT or ASGClpXP in both orientations. P = 7.8E-5 for the CTR from xAM imaging of cells expressing ASGClpXP versus CTR from xAM imaging of cells expressing ARGWT. P = 1.4E-6 for the CTR from xAM imaging of cells expressing ASGClpXP versus CTR from B-mode imaging of cells expressing ASGClpXP and P = 4.9E-7 for the CTR from xAM imaging of cells expressing ASGClpXP versus CTR from B-mode imaging of cells expressing ARGWT. Individual dots represent each N, and the thick horizontal line indicates the mean. Error bars indicate SEM. N = 9 mice. P-values were calculated using a two-tailed paired t-test for each comparison independently. Individual dots represent each N and horizontal line indicates the mean.
