Extended Data Fig. 4: Comparison of the structures of the 302TIL TCR bound to the HHATp8F and WT peptide-HLA-A*02:06 complexes. | Nature Chemical Biology

Extended Data Fig. 4: Comparison of the structures of the 302TIL TCR bound to the HHATp8F and WT peptide-HLA-A*02:06 complexes.

From: Structural dissimilarity from self drives neoepitope escape from immune tolerance

Extended Data Fig. 4

a, Superimposition of the TCR Vα/Vβ regions, peptides, and peptide binding grooves showing the overall similarities. The color scheme is given below and used for all panels. b, Cross-eyed stereo view of the TCR-peptide interface, highlighting the TCR interactions with Trp6 and Phe8/Leu8 of the peptides. c, As in panel b but rotated approximately 45° clockwise as indicated.

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