Extended Data Fig. 4: CTF Gαq signaling is detected both in CRE and NFκB.
From: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
CTF signaling in CRE, NFκB, and SRE was evaluated after 18 h of treatment with either vehicle or a potent Gαq inhibitor (YM-254890, 1 μM). Data was collected in regular HEK293T cells. Data points are normalized to empty vector control and displayed as the fold decrease with YM-254890. Bars show mean ±SEM from 4 independent experimental replicates.
